Trifluoroacetic acid → HCID 51037107, compound

HRID 2039537Notes

Reaction equation

HRID 2039537 reaction equation
C(OC(=O)[NH:7][C@@H:8]([C:15]1[N:24]2[N:25]=[C:26]([NH2:28])[N:27]=[C:23]2[C:22]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][C@H:8]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:15]1[N:24]2[N:25]=[C:26]([NH2:28])[N:27]=[C:23]2[C:22]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:16]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 51036891HCID 51036891, compound

Product 1

HCID 51037107HCID 51037107, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a suspension of [(R)-(2-amino-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-phenyl-methyl]-carbamic acid tert-butyl ester (0.05 g, 0.13 mmol), prepared as described in Example 49, in dichloromethane (4 mL), trifluoroacetic acid (1 mL) was added. The mixture was stirred at room temperature for 1 h, then the solvent was evaporated and the residue was diluted with ethyl acetate and washed with NaHCO3 satured solution then with water and brine. The organic phase was dried over Na2SO4, filtered and evaporated to provide the title compound (0.02 g, 65% yield).

Workup

  1. customprepared
  2. customthe solvent was evaporated
  3. additionthe residue was diluted with ethyl acetate
  4. washwashed with NaHCO3 satured solution
  5. dry with materialThe organic phase was dried over Na2SO4
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-3e6e5af8a4a1403d9aaadf7b3661b26a
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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