Morpholine → HCID 51037320, compound

HRID 2039539Notes

Reaction equation

HRID 2039539 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]3[N:20]4[N:21]=[C:22]([NH2:24])[N:23]=[C:19]4[C:18]4[CH:17]=[CH:16][C:15](F)=[CH:14][C:13]=4[N:12]=3)=[CH:9][C:4]=2[O:3][CH2:2]1.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][C:11]3[N:20]4[N:21]=[C:22]([NH2:24])[N:23]=[C:19]4[C:18]4[CH:17]=[CH:16][C:15]([N:26]5[CH2:31][CH2:30][O:29][CH2:28][CH2:27]5)=[CH:14][C:13]=4[N:12]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 51036893HCID 51036893, compound

Product 1

HCID 51037320HCID 51037320, compoundYield 50%

Conditions

Temperature
140 °C

Procedure

To 5-benzo[1,3]dioxol-5-ylmethyl-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine (0.05 g, 0.15 mmol), prepared as described in Example 21, morpholine (1 mL) was added and the mixture was heated at 140° C. for 2 h. The reaction was cooled at room temperature, the solid precipitated was filtered and washed with a mixture MeOH/H2O 9:1, to provide the title compound (0.03 g, 50% yield).

Workup

  1. additionwas added
  2. temperatureThe reaction was cooled at room temperature
  3. customthe solid precipitated
  4. filtrationwas filtered
  5. washwashed with a mixture MeOH/H2O 9:1

Sources & evidence

ORD record
ord-1b3afd97553645f2a1cdc02371251723
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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