3-Amino-1-propanol → HCID 51038621, compound

HRID 2039542Notes

Reaction equation

HRID 2039542 reaction equation
[CH2:1]([O:8][C:9]1[CH:30]=[CH:29][C:12]([CH2:13][C:14]2[N:23]3[N:24]=[C:25]([NH2:27])[N:26]=[C:22]3[C:21]3[CH:20]=[CH:19][C:18](F)=[CH:17][C:16]=3[N:15]=2)=[CH:11][C:10]=1[O:31][CH3:32])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1C2C=CC(CC3N4N=C(N)N=C4C4C=CC(F)=CC=4N=3)=CC=2OC1.[OH:58][CH2:59][CH2:60][CH2:61][NH2:62]>>[NH2:27][C:25]1[N:26]=[C:22]2[N:23]([C:14]([CH2:13][C:12]3[CH:29]=[CH:30][C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[C:10]([O:31][CH3:32])[CH:11]=3)=[N:15][C:16]3[CH:17]=[C:18]([NH:62][CH2:61][CH2:60][CH2:59][OH:58])[CH:19]=[CH:20][C:21]=32)[N:24]=1

Participants

4

Reactant 3

HCID 90863-Amino-1-propanolHCID 51036893HCID 51036893, compoundHCID 51038409HCID 51038409, compound

Product 1

HCID 51038621HCID 51038621, compoundYield 35%

Procedure

Operating as in Example 54, but employing 5-(4-benzyloxy-3-methoxy-benzyl)-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine prepared as described in Example 34 instead of 5-benzo[1,3]dioxol-5-ylmethyl-8-fluoro-[1,2,4]triazolo[1,5-c]quinazolin-2-ylamine and 3-hydroxy-propylamine instead of morpholine, the title compound was obtained in 35% yield.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-91c5a63fc50d47429f0567872fac850e
Source dataset
uspto-grants-2013_11
Patent number
US08580783B2

Reaction notes

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