Sodium Hydroxide → HCID 57855927, compound

HRID 2039618Notes

Reaction equation

HRID 2039618 reaction equation
C[O:2][C:3]([C:5]1[C:14]([NH2:15])=[C:13]([Cl:16])[C:8]2[N:9]([CH3:12])[CH:10]=[N:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+]>>[NH2:15][C:14]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]2[N:11]=[CH:10][N:9]([CH3:12])[C:8]=2[C:13]=1[Cl:16]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 57855960HCID 57855960, compound

Product 1

HCID 57855927HCID 57855927, compoundYield 87%

Procedure

See step d) of example H2 using 6-amino-7-chloro-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester as starting material and 1.5 equivalents of NaOH (1 N aqueous solution). After 5 h of stirring at ambient temperature and for 18 hours reaction at a temperature of 50° C., the solvents is evaporated and the work-up is made as already described. A total amount of 614 mg (2.72 mmol, 87%) of a pink-red solid were obtained. LC/MS: 226/228 (M+1)+.

Workup

  1. customreaction at a temperature of 50° C.
  2. customthe solvents is evaporated

Sources & evidence

ORD record
ord-e4d255b8df13495b93f78389b830005d
Source dataset
uspto-grants-2013_11
Patent number
US08580785B2

Reaction notes

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