Sodium Hydroxide → HCID 57855927, compound

Participants

Reaction Steps

See step d) of example H2 using 6-amino-7-chloro-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester as starting material and 1.5 equivalents of NaOH (1 N aqueous solution). After 5 h of stirring at ambient temperature and for 18 hours reaction at a temperature of 50° C., the solvents is evaporated and the work-up is made as already described. A total amount of 614 mg (2.72 mmol, 87%) of a pink-red solid were obtained. LC/MS: 226/228 (M+1)+.

Provenance & Evidence