tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-(5-iodopyridin-2-yl)piperazine-1-carboxylate

HRID 2039653Notes

Reaction equation

HRID 2039653 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=1.[C:9]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10]>>[C:12]([O:11][C:9]([N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:7]=[CH:6][C:5]([I:8])=[CH:4][N:3]=2)[CH2:18][CH2:17]1)=[O:10])([CH3:15])([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 27831792-Fluoro-5-iodopyridine

Product 1

HCID 7164639tert-Butyl 4-(5-iodopyridin-2-yl)piperazine-1-carboxylate

Procedure

By carrying out the procedure as described in preparation 1, but using 2-fluoro-5-iodopyridine instead of 2-chloro-5-(trifluoromethyl)pyridine and N-Boc-piperazine instead of cis-2,6-dimethylpiperazine, the title compound is obtained in the form of an oil.

Workup

  1. customas described in preparation 1

Sources & evidence

ORD record
ord-5cd8d665315045cc83555fb12ba1b909
Source dataset
uspto-grants-2013_11
Patent number
US08580790B2

Reaction notes

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