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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2039653Generated: October 25, 2026

tert-Butyl piperazine-1-carboxylate → tert-Butyl 4-(5-iodopyridin-2-yl)piperazine-1-carboxylate

https://huagongshe.com/reaction/2039653

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant2-Fluoro-5-iodopyridineHCID 2783179—
Producttert-Butyl 4-(5-iodopyridin-2-yl)piperazine-1-carboxylateHCID 7164639—

Reaction Steps

By carrying out the procedure as described in preparation 1, but using 2-fluoro-5-iodopyridine instead of 2-chloro-5-(trifluoromethyl)pyridine and N-Boc-piperazine instead of cis-2,6-dimethylpiperazine, the title compound is obtained in the form of an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08580790B2
Source datasetuspto-grants-2013_11
ORD IDord-5cd8d665315045cc83555fb12ba1b909
Source noteuspto-grants-2013_11