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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2039670Generated: October 30, 2026

HCID 16214898, compound → 4-{4-[3-(6-Trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide

https://huagongshe.com/reaction/2039670

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 16214898HCID 16214898—
Reactant4-(4-Aminophenoxy)-N-methylpicolinamideHCID 16655129—
SolventEthyl AcetateHCID 8857—
Product4-{4-[3-(6-Trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamideHCID 23634270—

Reaction Steps

The title compound was prepared in the same manner as 4-{3-fluoro-4-[3-(6-trifluoromethylpyrimidin-4-yl)ureido]phenoxy}pyridine-2-carboxylic-acid methylamide, replacing 4-(4-amino-3-fluoro-phenoxy)pyridine-2-carboxylic acid methylamide for 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide. LC-MS m/z 433.1 [M+H]+; TLC Rf=0.8 (EtOAc).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08580798B2
Source datasetuspto-grants-2013_11
ORD IDord-c60f33495c5745acaed33212022146a8
Source noteuspto-grants-2013_11