HCID 16214898, compound → 4-{4-[3-(6-Trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide

HRID 2039670Notes

Reaction equation

HRID 2039670 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[N:25]=[CH:24][N:23]=3)=[O:20])=[C:14](F)[CH:13]=2)[CH:8]=[CH:7][N:6]=1)=[O:4].CNC(C1C=C(OC2C=CC(N)=CC=2)C=CN=1)=O>CCOC(C)=O>[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([C:28]([F:31])([F:29])[F:30])[N:25]=[CH:24][N:23]=3)=[O:20])=[CH:16][CH:17]=2)[CH:8]=[CH:7][N:6]=1)=[O:4]

Participants

4

Reactant 2

HCID 16214898HCID 16214898, compoundHCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

Product 1

HCID 236342704-{4-[3-(6-Trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic acid methylamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in the same manner as 4-{3-fluoro-4-[3-(6-trifluoromethylpyrimidin-4-yl)ureido]phenoxy}pyridine-2-carboxylic-acid methylamide, replacing 4-(4-amino-3-fluoro-phenoxy)pyridine-2-carboxylic acid methylamide for 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide. LC-MS m/z 433.1 [M+H]+; TLC Rf=0.8 (EtOAc).

Sources & evidence

ORD record
ord-c60f33495c5745acaed33212022146a8
Source dataset
uspto-grants-2013_11
Patent number
US08580798B2

Reaction notes

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