HCID 16214898, compound → HCID 23634271, compound

HRID 2039671Notes

Reaction equation

HRID 2039671 reaction equation
CN[C:3]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[N:25]=[CH:24][N:23]=3)=[O:20])=[C:14](F)[CH:13]=2)[CH:8]=[CH:7][N:6]=1)=O.CNC(C1C(OC2C=CC(N)=C(F)C=2)=CC=CN=1)=O.CC1C=C(OC2C=CC(N)=CC=2)C=CN=1>CCOC(C)=O>[F:31][C:28]([F:29])([F:30])[C:26]1[N:25]=[CH:24][N:23]=[C:22]([NH:21][C:19](=[O:20])[NH:18][C:15]2[CH:16]=[CH:17][C:12]([O:11][C:9]3[CH:8]=[CH:7][N:6]=[C:5]([CH3:3])[CH:10]=3)=[CH:13][CH:14]=2)[CH:27]=1

Participants

5

Reactant 3

HCID 16214898HCID 16214898, compoundHCID 230230754-(2-Methyl-4-pyridinyloxy)anilineHCID 86640576HCID 86640576, compound

Product 1

HCID 23634271HCID 23634271, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

The title compound was prepared in the same manner as 4-{3-fluoro-4-[3-(6-trifluoromethyl-pyrimidin-4-yl)-ureido]-phenoxy}-pyridine-2-carboxylic-acid methyl-amide, replacing 4-(4-amino-3-fluorophenoxypyridine-2-carboxylic acid methylamide for 4-(2-methylpyridin-4-yloxy)phenylamine. LC-MS m/z 389.9 [M+H]+; TLC Rf=0.45 (EtOAc).

Sources & evidence

ORD record
ord-97a606810d5848c1b051513e0f590888
Source dataset
uspto-grants-2013_11
Patent number
US08580798B2

Reaction notes

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