(3-Methylbutyl)hydrazine → HCID 58266285, compound

HRID 2039700Notes

Reaction equation

HRID 2039700 reaction equation
Br[CH2:2][C:3]1[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=2)[C:7](=[O:19])[NH:6][C@H:5]([C:20]2[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=2)[C:4]=1[C:28]([O:30]CC)=O.[CH3:33][CH:34]([CH3:39])[CH2:35][CH2:36][NH:37][NH2:38]>O1CCOCC1>[CH3:33][CH:34]([CH3:39])[CH2:35][CH2:36][N:37]1[CH2:2][C:3]2[N:8]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)[C:7](=[O:19])[NH:6][C@H:5]([C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)[C:4]=2[C:28](=[O:30])[NH:38]1

Participants

4

Reactant 2

HCID 18696583(3-Methylbutyl)hydrazineHCID 58266264HCID 58266264, compound

Product 1

HCID 58266285HCID 58266285, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
120 °C

Procedure

150 mg (0.295 mmol) of the compound from Example 6A were dissolved in 3 ml of dioxane, and 91 mg (0.885 mmol) of (3-methylbutyl)hydrazine were added. The mixture was stirred at 120° C. for 3 h and then concentrated. The residue was taken up in DMSO and purified by preparative HPLC (Method 10). This gave 43 mg (29% of theory) of the target compound.

Workup

  1. concentrationconcentrated
  2. custompurified by preparative HPLC (Method 10)

Sources & evidence

ORD record
ord-be4d04f3973a45b0b4fd368f7ecbe6d9
Source dataset
uspto-grants-2013_11
Patent number
US08580800B2

Reaction notes

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