HCID 58961526, compound → HCID 58327737, compound

HRID 2039743Notes

Reaction equation

HRID 2039743 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[NH2:15])[CH2:7][CH2:6]1.Cl[C:21]1[C:22]2[C:29]([C:30]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[O:31])=[CH:28][NH:27][C:23]=2[N:24]=[CH:25][N:26]=1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[NH:15][C:21]2[C:22]3[C:29]([C:30]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)=[O:31])=[CH:28][NH:27][C:23]=3[N:24]=[CH:25][N:26]=2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 58961526HCID 58961526, compoundHCID 67252096HCID 67252096, compound

Product 1

HCID 58327737HCID 58327737, compound

Procedure

(4-((2-(2-(4-(2-Methoxyethyl)piperazin-1-yl)ethyl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(phenyl)methanone was synthesized using 2-(2-(4-(2-methoxyethyl)piperazin-1-yl)ethyl)aniline and (4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(phenyl)methanone according to the general procedure A. A white solid was obtained. M.p.=192-193° C.; 400 MHz 1HNMR (DMSO-d6) δ 10.66 (s, 1H), 8.31 (s, 1H), 7.98-7.94 (m, 2H), 7.84-7.82 (m, 2H), 7.70-7.66 (m, 1H), 7.60-7.57 (m, 2H), 7.30-7.25 (m, 2H), 7.13-7.09 (m, 1H), 3.33 (t, J=6.0 Hz, 4H), 3.32 (s, 3H), 2.90 (d, J=8.0 Hz, 2H), 2.51-2.46 (m, 4H), 2.36-2.33 (m, 4H), 2.24 (bs, 2H); LCMS [M+H] 463.

Workup

  1. customA white solid was obtained

Sources & evidence

ORD record
ord-770bfe7b41b44ded95a83b10a36a8658
Source dataset
uspto-grants-2013_11
Patent number
US08580803B2

Reaction notes

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