3-Amino-N-methylbenzamide → HCID 58327706, compound

HRID 2039746Notes

Reaction equation

HRID 2039746 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH:7][CH3:8])=[O:6].Cl[C:13]1[C:14]2[C:21]([C:22]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[CH3:30])=[O:23])=[CH:20][NH:19][C:15]=2[N:16]=[CH:17][N:18]=1>>[CH3:8][NH:7][C:5](=[O:6])[C:4]1[CH:9]=[CH:10][CH:11]=[C:2]([NH:1][C:13]2[C:14]3[C:21]([C:22](=[O:23])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[CH3:30])=[CH:20][NH:19][C:15]=3[N:16]=[CH:17][N:18]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 6765263-Amino-N-methylbenzamideHCID 86654847HCID 86654847, compound

Product 1

HCID 58327706HCID 58327706, compound

Procedure

N-Methyl-3-((5-(2-methylbenzoyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzamide was synthesized using 3-amino-N-methylbenzamide and ((4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)(o-tolyl)methanone according to the general procedure A. An off-white solid was obtained. M.p.>300° C.; 400 MHz 1HNMR (DMSO-d6) δ 11.47 (s, 1H), 8.48-8.47 (m, 2H), 8.24-8.20 (m, 2H), 7.60 (s, 1H), 7.52-7.45 (m, 4H), 7.40-7.32 (m, 2H), 2.86 (d, J=4.4 Hz, 3H), 2.34 (s, 3H); LCMS [M+H] 386.

Workup

  1. customAn off-white solid was obtained

Sources & evidence

ORD record
ord-c3a58b6433824a9da15288da1504dc8c
Source dataset
uspto-grants-2013_11
Patent number
US08580803B2

Reaction notes

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