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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2039763Generated: November 2, 2026

Trifluoroacetic acid → HCID 71186361, compound

https://huagongshe.com/reaction/2039763

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantTert-butyl {4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}acetateHCID 71187226—
SolventDichloromethaneHCID 6344—
ProductHCID 71186361HCID 71186361—

Reaction Steps

1 ml of trifluoroacetic acid was added to a solution of 170 mg of tert-butyl {4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}acetate in 3 ml of dichloromethane, and the mixture was stirred at room temperature for 16 h. The reaction was then concentrated under reduced pressure, purified by preparative HPLC and freeze-dried. This gave 85 mg (57%) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08580816B2
Source datasetuspto-grants-2013_11
ORD IDord-980ca7c0bbfd460c828247ad49a4df91
Source noteuspto-grants-2013_11