Trifluoroacetic acid → HCID 71186361, compound

HRID 2039763Notes

Reaction equation

HRID 2039763 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:41]=[CH:40][CH:39]=[CH:38][C:10]=1[O:11][C:12]1[N:17]=[C:16]2[O:18][C:19]([C:21]3[CH:35]=[C:34]([CH3:36])[C:24]([O:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[C:23]([CH3:37])[CH:22]=3)=[N:20][C:15]2=[CH:14][CH:13]=1>ClCCl>[F:8][C:9]1[CH:41]=[CH:40][CH:39]=[CH:38][C:10]=1[O:11][C:12]1[N:17]=[C:16]2[O:18][C:19]([C:21]3[CH:22]=[C:23]([CH3:37])[C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[C:34]([CH3:36])[CH:35]=3)=[N:20][C:15]2=[CH:14][CH:13]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71187226Tert-butyl {4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}acetate

Product 1

HCID 71186361HCID 71186361, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1 ml of trifluoroacetic acid was added to a solution of 170 mg of tert-butyl {4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}acetate in 3 ml of dichloromethane, and the mixture was stirred at room temperature for 16 h. The reaction was then concentrated under reduced pressure, purified by preparative HPLC and freeze-dried. This gave 85 mg (57%) of the title compound.

Workup

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. custompurified by preparative HPLC
  3. customfreeze-dried

Sources & evidence

ORD record
ord-980ca7c0bbfd460c828247ad49a4df91
Source dataset
uspto-grants-2013_11
Patent number
US08580816B2

Reaction notes

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