Benzyl 3-hydroxy-2,2-dimethylpropanoate → Benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionate

HRID 2039766Notes

Reaction equation

HRID 2039766 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[O:4][C:5]1[N:10]=[C:9]2[O:11][C:12]([C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([OH:21])=[C:16]([CH3:22])[CH:15]=3)=[N:13][C:8]2=[CH:7][CH:6]=1.O[CH2:28][C:29]([CH3:41])([CH3:40])[C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31]>>[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[O:4][C:5]1[N:10]=[C:9]2[O:11][C:12]([C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([O:21][CH2:28][C:29]([CH3:41])([CH3:40])[C:30]([O:32][CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:31])=[C:16]([CH3:22])[CH:15]=3)=[N:13][C:8]2=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 18922595Benzyl 3-hydroxy-2,2-dimethylpropanoateHCID 1364132384-[5-(2-Fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenol

Product 1

HCID 71186253Benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionateYield 41.5%

Procedure

Analogously to Example 3 (step (a)), the reaction of 250 mg of 4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenol with 178 mg of benzyl 3-hydroxy-2,2-dimethylpropionate gave 160 mg (41%) of benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionate.

Sources & evidence

ORD record
ord-ceb200f44b1f49c5a99275004e441af7
Source dataset
uspto-grants-2013_11
Patent number
US08580816B2

Reaction notes

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