HRID2039766

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18922595

Benzyl 3-hydroxy-2,2-dimethylpropanoate

C12H16O3

结构：Cc1cc(-c2nc3ccc(Oc4ccccc4F)nc3o2)cc(C)c1O

HCID136413238

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(-c2nc3ccc(Oc4ccccc4F)nc3o2)cc(C)c1OCC(C)(C)C(=O)OCc1ccccc1

HCID71186253

未命名化合物

收率 41.5%

PROCEDURE

实验过程

Analogously to Example 3 (step (a)), the reaction of 250 mg of 4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenol with 178 mg of benzyl 3-hydroxy-2,2-dimethylpropionate gave 160 mg (41%) of benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ceb200f44b1f49c5a99275004e441af7
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08580816B2
来源说明: uspto-grants-2013_11

反应 SMILES

[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[O:4][C:5]1[N:10]=[C:9]2[O:11][C:12]([C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([OH:21])=[C:16]([CH3:22])[CH:15]=3)=[N:13][C:8]2=[CH:7][CH:6]=1.O[CH2:28][C:29]([CH3:41])([CH3:40])[C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31]>>[F:1][C:2]1[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=1[O:4][C:5]1[N:10]=[C:9]2[O:11][C:12]([C:14]3[CH:19]=[C:18]([CH3:20])[C:17]([O:21][CH2:28][C:29]([CH3:41])([CH3:40])[C:30]([O:32][CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:31])=[C:16]([CH3:22])[CH:15]=3)=[N:13][C:8]2=[CH:7][CH:6]=1