HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 3-hydroxy-2,2-dimethylpropanoate → Benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 3-hydroxy-2,2-dimethylpropanoate | HCID 18922595 | — |
| Reactant | 4-[5-(2-Fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenol | HCID 136413238 | — |
| Product | Benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionate | HCID 71186253 | 41.5% |
Reaction Steps
Analogously to Example 3 (step (a)), the reaction of 250 mg of 4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenol with 178 mg of benzyl 3-hydroxy-2,2-dimethylpropionate gave 160 mg (41%) of benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-b]pyridin-2-yl]-2,6-dimethylphenoxy}-2,2-dimethylpropionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580816B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-ceb200f44b1f49c5a99275004e441af7 |
| Source note | uspto-grants-2013_11 |