HCID 70840036, compound → HCID 25095370, compound

HRID 2039786Notes

Reaction equation

HRID 2039786 reaction equation
[C:1]12([CH2:11][NH:12][C:13]([C:15]3[C:16]4[N:17]([N:21]=[C:22]([CH:24]=[CH:25][C:26]#[N:27])[CH:23]=4)[CH:18]=[CH:19][CH:20]=3)=[O:14])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>CO.[Pd]>[C:1]12([CH2:11][NH:12][C:13]([C:15]3[C:16]4[N:17]([N:21]=[C:22]([CH2:24][CH2:25][C:26]#[N:27])[CH:23]=4)[CH:18]=[CH:19][CH:20]=3)=[O:14])[CH2:8][CH:7]3[CH2:9][CH:3]([CH2:4][CH:5]([CH2:6]3)[CH2:10]1)[CH2:2]2

Participants

4

Reactant 1

HCID 70840036HCID 70840036, compound

Product 1

HCID 25095370HCID 25095370, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Pd/C (50 mg) is added to a solution of 2-(2-cyano-vinyl)-pyrazolo[1,5-a]pyridine-4-carboxylic acid (adamantan-1-ylmethyl)-amide in MeOH. The mixture is stirred under hydrogen balloon for 6 h. The mixture is filtered through celite and the celite and solvent are removed to give the title compound. LC-MS m/z (M+H+): 363.

Workup

  1. filtrationThe mixture is filtered through celite
  2. customthe celite and solvent are removed

Sources & evidence

ORD record
ord-fcb6bed4dbb54e549007aca2ea6b73da
Source dataset
uspto-grants-2013_11
Patent number
US08580812B2

Reaction notes

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