Chloride → HCID 86621105, compound

HRID 2039812Notes

Reaction equation

HRID 2039812 reaction equation
O[CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1.[Cl-:18]>>[Cl:18][CH2:2][C:3]1[CH:17]=[CH:16][C:6]([O:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 312ChlorideHCID 22340602Butanoic acid, 4-[4-(hydroxymethyl)phenoxy]-, ethyl ester

Product 1

HCID 86621105HCID 86621105, compound

Procedure

Ethyl 4-(4-(chloromethyl)phenoxy)butanoate 13i was prepared from 29b according to the protocol described for the compound 13h in Example 26 (Scheme 9). The title chloride 13i was isolated as colorless oil in 96% yield (1.25 g). 1H NMR (400 MHz, CDCl3): δ 1.24 (3H, t, J=7.2 Hz); 2.06 (2H, m); 2.18 (2H, t, J=7.2 Hz)); 4.00 (2H, t, J=6.4 Hz); 4.14 (2H, q, J=7.2 Hz); 4.54 (2H, s); 6.83 (1H, s); 6.86 (1H, s); 7.27 (1H, m); 7.29 (1H, s). MS (ESI): m/z=258.10 (M+H+).

Sources & evidence

ORD record
ord-6e8e32e601ff4f90a6c1cf2f8e2faebd
Source dataset
uspto-grants-2013_11
Patent number
US08580822B2

Reaction notes

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