Hydrochloric Acid → HCID 44158795, compound

HRID 2039816Notes

Reaction equation

Cl.Cl.Cl.[F:4][C:5]1[C:6]([CH3:37])=[C:7]([CH:34]=[CH:35][CH:36]=1)[CH2:8][C:9]1[N:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16]2[C:11](=[N:12][C:13]([O:24][CH3:25])=[CH:14][CH:15]=2)[C:10]=1[C:26]([N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)=[O:27]>>[F:4][C:5]1[C:6]([CH3:37])=[C:7]([CH:34]=[CH:35][CH:36]=1)[CH2:8][C:9]1[N:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:16]2[C:11](=[N:12][C:13]([O:24][CH3:25])=[CH:14][CH:15]=2)[C:10]=1[C:26]([N:28]1[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]1)=[O:27]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 66922291HCID 66922291, compound

Product 1

HCID 44158795HCID 44158795, compound

Procedure

The compound of step 6 (23 mg, 41.2 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 15.9 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-5-methoxy-1-phenyl-1H-pyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

dissolutionDissolution of the obtained solid

Sources & evidence

ORD record: ord-d1dd3369e68b4497a6876ed97b4fc44e
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580813B2

Reaction notes

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