Hydrochloric Acid → HCID 44159021, compound

HRID 2039823Notes

Reaction equation

HRID 2039823 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][N:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[CH2:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([F:38])[C:33]=2[CH3:39])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C(C)=C(C=CC=1)CC1N(C2C=CC=CC=2)C2=CN=CC=C2C=1C(N1CCNCC1)=O>>[F:38][C:34]1[C:33]([CH3:39])=[C:32]([CH:37]=[CH:36][CH:35]=1)[CH2:31][C:17]1[N:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2=[CH:20][N:21]=[CH:22][CH:23]=[C:24]2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922234HCID 66922234, compoundHCID 66922324HCID 66922324, compound

Product 1

HCID 44159021HCID 44159021, compoundYield 37.3%

Procedure

The compound of step 1 (120 mg, 226 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 36.1 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-0dbca4ecdc574f72b484a72d3b61b6a0
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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