Hydrochloric Acid → HCID 44159022, compound

HRID 2039825Notes

Reaction equation

HRID 2039825 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][N:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:31][C:32]2[CH:37]=[C:36]([F:38])[CH:35]=[CH:34][C:33]=2[CH3:39])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C=CC(C)=C(C=1)OC1N(C2C=CC=CC=2)C2=CN=CC=C2C=1C(N1CCNCC1)=O>>[F:38][C:36]1[CH:35]=[CH:34][C:33]([CH3:39])=[C:32]([CH:37]=1)[O:31][C:17]1[N:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2=[CH:20][N:21]=[CH:22][CH:23]=[C:24]2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922183HCID 66922183, compoundHCID 66922239HCID 66922239, compound

Product 1

HCID 44159022HCID 44159022, compound

Procedure

The crude compound of step 1 was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 25.9 mg of the title compound in the form of [2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-4441ddffabde4db1aeecb01ac4abba8c
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

Loading…