Hydrochloric Acid → HCID 56661825, compound

HRID 2039835Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2[CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:35]=2[CH3:41])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C(C)=C(C=CC=1)CC1N(C2C=CC=CC=2)C2=NC=C(OC)C=C2C=1C(N1CCNCC1)=O>>[F:40][C:36]1[C:35]([CH3:41])=[C:34]([CH:39]=[CH:38][CH:37]=1)[CH2:33][C:17]1[N:18]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:19]2=[N:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=[C:24]2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 66922184HCID 66922184, compound

HCID 66922411HCID 66922411, compound

Product 1

HCID 56661825HCID 56661825, compoundYield 61.3%

Procedure

The compound of step 1 (35.0 mg, 62.6 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 17.6 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-5-methoxy-1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

dissolutionDissolution of the obtained solid

Sources & evidence

ORD record: ord-90395e376669458da54b9ee32083ec08
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580813B2

Reaction notes

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