HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → [2-(3-Fluoro-2-methyl-benzyl)-6-methoxy-1-phenyl-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | [2-(3-fluoro-2-methyl-benzyl)-6-methoxy-1-phenyl-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride | HCID 66922211 | — |
| Reactant | HCID 66922349 | HCID 66922349 | — |
| Product | [2-(3-Fluoro-2-methyl-benzyl)-6-methoxy-1-phenyl-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone | HCID 53387514 | 82.3% |
Reaction Steps
The compound of step 7 (33 mg, 59.1 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 22.3 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-6-methoxy-1-phenyl-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08580813B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-3d7b612d03114a9399b34681b5d87381 |
| Source note | uspto-grants-2013_11 |