HRID2039838

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1cc2c(cn1)c(C(=O)N1CCNCC1)c(Cc1cccc(F)c1C)n2-c1ccccc1.Cl.Cl

HCID66922211

未命名化合物

结构：COc1cc2c(cn1)c(C(=O)N1CCN(C(=O)OC(C)(C)C)CC1)c(Cc1cccc(F)c1C)n2-c1ccccc1

HCID66922349

未命名化合物

PRODUCTS

生成物

结构：COc1cc2c(cn1)c(C(=O)N1CCNCC1)c(Cc1cccc(F)c1C)n2-c1ccccc1

HCID53387514

未命名化合物

收率 82.3%

PROCEDURE

实验过程

The compound of step 7 (33 mg, 59.1 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 22.3 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-6-methoxy-1-phenyl-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

WORKUP

后处理

dissolutionDissolution of the obtained solid

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3d7b612d03114a9399b34681b5d87381
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08580813B2
来源说明: uspto-grants-2013_11

反应 SMILES

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3[CH:21]=[N:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=3[N:18]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:17]=2[CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:35]=2[CH3:41])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C(C)=C(C=CC=1)CC1N(C2C=CC=CC=2)C2C=C(OC)N=CC=2C=1C(N1CCNCC1)=O>>[F:40][C:36]1[C:35]([CH3:41])=[C:34]([CH:39]=[CH:38][CH:37]=1)[CH2:33][C:17]1[N:18]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[N:22]=[CH:21][C:20]=2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]