Hydrochloric Acid → HCID 44194118, compound

HRID 2039842Notes

Reaction equation

HRID 2039842 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[CH:20][N:21]=[CH:22][CH:23]=3)[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:31][C:32]2[C:37]([CH3:38])=[CH:36][CH:35]=[C:34]([F:39])[C:33]=2[CH3:40])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C(C)=C(C(C)=CC=1)OC1N(C2C=CC=CC=2)C2=CN=CC=C2C=1C(N1CCNCC1)=O>>[F:39][C:34]1[C:33]([CH3:40])=[C:32]([C:37]([CH3:38])=[CH:36][CH:35]=1)[O:31][C:17]1[N:18]([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[C:19]2=[CH:20][N:21]=[CH:22][CH:23]=[C:24]2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922122HCID 66922122, compoundHCID 66922426HCID 66922426, compound

Product 1

HCID 44194118HCID 44194118, compound

Procedure

The crude compound of step 1 was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 42 mg of the title compound in the form of [2-(3-fluoro-2,6-dimethyl-phenoxy)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-65b5551ebe814e4aba6aeca3b2de9835
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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