Hydrochloric Acid → HCID 53346499, compound

HRID 2039846Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[C:20]([CH2:25][C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[N:21]=[CH:22][CH:23]=3)[N:18]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:17]=2[O:38][C:39]2[CH:44]=[C:43]([F:45])[CH:42]=[CH:41][C:40]=2[CH3:46])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.C(C1N=CC=C2C(C(N3CCNCC3)=O)=C(OC3C=C(F)C=CC=3C)N(C3C=CC=CC=3)C=12)C1C=CC=CC=1>>[CH2:25]([C:20]1[N:21]=[CH:22][CH:23]=[C:24]2[C:16]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[O:15])=[C:17]([O:38][C:39]3[CH:44]=[C:43]([F:45])[CH:42]=[CH:41][C:40]=3[CH3:46])[N:18]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C:19]=12)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 66922138HCID 66922138, compound

HCID 66922359HCID 66922359, compound

Product 1

HCID 53346499HCID 53346499, compoundYield 112.1%

Procedure

The compound of step 1 (37 mg, 60 μmol) was reacted analogously as described in example 4, step 2. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 35 mg of the title compound in the form of the [7-benzyl-2-(5-fluoro-2-methyl-phenoxy)-1-phenyl-1H-pyrrolo[2,3-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

dissolutionDissolution of the obtained solid

Sources & evidence

ORD record: ord-0fdd1105c51047d6a81f096ee7a7931a
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08580813B2

Reaction notes

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