Hydrochloric Acid → HCID 56672195, compound

HRID 2039853Notes

Reaction equation

HRID 2039853 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:24]3[C:19](=[N:20][CH:21]=[CH:22][C:23]=3[CH2:25][CH2:26][CH3:27])[N:18]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:17]=2[CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([F:41])[C:36]=2[CH3:42])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.FC1C(C)=C(C=CC=1)CC1N(C2C=CC=CC=2)C2=NC=CC(CCC)=C2C=1C(N1CCNCC1)=O>>[F:41][C:37]1[C:36]([CH3:42])=[C:35]([CH:40]=[CH:39][CH:38]=1)[CH2:34][C:17]1[N:18]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[C:19]2=[N:20][CH:21]=[CH:22][C:23]([CH2:25][CH2:26][CH3:27])=[C:24]2[C:16]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922306HCID 66922306, compoundHCID 66922344HCID 66922344, compound

Product 1

HCID 56672195HCID 56672195, compoundYield 62.3%

Procedure

The compound of step 1 (175 mg, 307 μmol) was reacted analogously as described in example 4, step 2. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 90 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-1-phenyl-4-propyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-e43561875cac4575bcad0f8c2a1e98af
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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