Hydrochloric Acid → HCID 56665264, compound

HRID 2039855Notes

Reaction equation

HRID 2039855 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3[CH:21]=[N:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=3[N:18]([CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[C:17]=2[CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:35]=2[CH3:41])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.C1(N2C3C=C(OC)N=CC=3C(C(N3CCNCC3)=O)=C2CC2C=CC=C(F)C=2C)CCCCC1>>[CH:27]1([N:18]2[C:19]3[CH:24]=[C:23]([O:25][CH3:26])[N:22]=[CH:21][C:20]=3[C:16]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[O:15])=[C:17]2[CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([F:40])[C:35]=2[CH3:41])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922366HCID 66922366, compoundHCID 66922382HCID 66922382, compound

Product 1

HCID 56665264HCID 56665264, compoundYield 67.5%

Procedure

The compound of step 8 (38 mg, 67 μmol) was reacted analogously as described in example 4, step 2. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 21 mg of the title compound in the form of the [1-cyclohexyl-2-(3-fluoro-2-methyl-benzyl)-6-methoxy-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-95d8b307b89e4690ae4d6c8afd570740
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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