Hydrochloric Acid → HCID 56665266, compound

HRID 2039857Notes

Reaction equation

HRID 2039857 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3[CH:21]=[N:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=3[N:18]([CH:27]3[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[C:17]=2[O:33][C:34]2[C:39]([CH3:40])=[CH:38][CH:37]=[CH:36][C:35]=2[CH3:41])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.Cl.Cl.C1(N2C3C=C(OC)N=CC=3C(C(N3CCNCC3)=O)=C2OC2C(C)=CC=CC=2C)CCCCC1>>[CH:27]1([N:18]2[C:19]3[CH:24]=[C:23]([O:25][CH3:26])[N:22]=[CH:21][C:20]=3[C:16]([C:14]([N:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[O:15])=[C:17]2[O:33][C:34]2[C:35]([CH3:41])=[CH:36][CH:37]=[CH:38][C:39]=2[CH3:40])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922229HCID 66922229, compoundHCID 66922412HCID 66922412, compound

Product 1

HCID 56665266HCID 56665266, compoundYield 77.5%

Procedure

The compound of step 1 (52 mg, 92 μmol) was reacted analogously as described in example 1, step 7. Dissolution of the obtained solid in a small quantity of MOH, addition of hydrochloric acid (0.1 M) and lyophilization overnight yielded 33 mg of the title compound in the form of the [1-cyclohexyl-2-(2,6-dimethyl-phenoxy)-6-methoxy-1H-pyrrolo[3,2-c]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionDissolution of the obtained solid

Sources & evidence

ORD record
ord-f265bea39c044a34b16cd053fe292cb9
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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