Hydrochloric Acid → HCID 56665122, compound

HRID 2039861Notes

Reaction equation

HRID 2039861 reaction equation
FC1C(C)=C(C=CC=1)CC1N(C2C=CC=CC=2)C2C(=NC=C(C)C=2)C=1C(O)=O.Cl.Cl.Cl.[F:32][C:33]1[C:34]([CH3:64])=[C:35]([CH:61]=[CH:62][CH:63]=1)[CH2:36][C:37]1[N:45]([C:46]2[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=2)[C:44]2[C:39](=[N:40][CH:41]=[C:42]([CH3:52])[CH:43]=2)[C:38]=1[C:53]([N:55]1[CH2:60][CH2:59][NH:58][CH2:57][CH2:56]1)=[O:54]>>[F:32][C:33]1[C:34]([CH3:64])=[C:35]([CH:61]=[CH:62][CH:63]=1)[CH2:36][C:37]1[N:45]([C:46]2[CH:47]=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:44]2[C:39](=[N:40][CH:41]=[C:42]([CH3:52])[CH:43]=2)[C:38]=1[C:53]([N:55]1[CH2:56][CH2:57][NH:58][CH2:59][CH2:60]1)=[O:54]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922208HCID 66922208, compoundHCID 66922231HCID 66922231, compound

Product 1

HCID 56665122HCID 56665122, compound

Procedure

The crude compound of step 8 (60 mg) was reacted analogously as described in example 1, step 5 and subsequently as described in example 4, step 2. The obtained solid was dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight to give 6.4 mg of the title compound in the form of the [2-(3-fluoro-2-methyl-benzyl)-6-methyl-1-phenyl-1H-pyrrolo[3,2-b]pyridin-3-yl]-piperazin-1-yl-methanone dihydrochloride.

Workup

  1. dissolutionThe obtained solid was dissolved in a small quantity of MOH

Sources & evidence

ORD record
ord-fe26d9e354914c02adb408bf60a7daa4
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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