Hydrochloric Acid → HCID 56668563, compound

HRID 2039871Notes

Reaction equation

HRID 2039871 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[C:20]3=[N:21][CH:22]=[CH:23][CH:24]=[C:19]3[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:31][C:32]2[C:37]([CH3:38])=[CH:36][CH:35]=[CH:34][C:33]=2[CH3:39])=[O:15])[CH2:10][CH:9]1[CH2:40][C:41]([O:43][CH3:44])=[O:42])=O)(C)(C)C.Cl.Cl.Cl.COC(=O)CC1CN(C(C2C3=NC=CC=C3N(C3C=CC=CC=3)C=2OC2C(C)=CC=CC=2C)=O)CCN1>>[CH3:44][O:43][C:41](=[O:42])[CH2:40][CH:9]1[CH2:10][N:11]([C:14]([C:16]2[C:20]3=[N:21][CH:22]=[CH:23][CH:24]=[C:19]3[N:18]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:17]=2[O:31][C:32]2[C:33]([CH3:39])=[CH:34][CH:35]=[CH:36][C:37]=2[CH3:38])=[O:15])[CH2:12][CH2:13][NH:8]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 66922257HCID 66922257, compoundHCID 66922395HCID 66922395, compound

Product 1

HCID 56668563HCID 56668563, compoundYield 39%

Procedure

The crude compound of step 2 (40 mg) was reacted analogously as described in example 1, step 7, the obtained product dissolved in a small quantity of MOH, mixed with hydrochloric acid (0.1 M) and lyophilized overnight to give 13 mg of the title compound in the form of the {4-[2-(2,6-dimethyl-phenoxy)-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl]-piperazin-2-yl}-acetic acid methyl ester dihydrochloride.

Workup

  1. dissolutionthe obtained product dissolved in a small quantity of MOH

Sources & evidence

ORD record
ord-1630a82b51424e778ec20bdf46a0a272
Source dataset
uspto-grants-2013_11
Patent number
US08580813B2

Reaction notes

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