反应详情

A flask is charged with 200 mg (0.49 mmol) of 2-bromo-N-(2-(bromomethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide (stage 1) and 5 mL of methanol. The solution is stirred at room temperature for 18 hours and then diluted in 100 mL of ethyl acetate, washed with 3×30 mL of water, dried over sodium sulphate and evaporated under reduced pressure. The raw product is then purified by silica gel chromatography (ethyl acetate/petroleum ether eluent). 30 mg of a yellow solid is obtained (17%).

1. washwashed with 3×30 mL of water
2. dry with materialdried over sodium sulphate
3. customevaporated under reduced pressure
4. customThe raw product is then purified by silica gel chromatography (ethyl acetate/petroleum ether eluent)