Benzoyl chloride → HCID 68756964, compound

HRID 2039971Notes

Reaction equation

HRID 2039971 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[NH:8][C:5]2=[N:6][CH:7]=1.[C:15](Cl)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:15]([NH:1][C:2]1[CH:3]=[C:4]2[CH:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[NH:8][C:5]2=[N:6][CH:7]=1)(=[O:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 40152010Methyl 5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Product 1

HCID 68756964HCID 68756964, compoundYield 55.4%

Procedure

The compound is prepared according to the protocol described in example A (stage 2) using 200 mg (1.04 mmol) of methyl 5-amino-1H-pyrrolo[2,3-b]pyridine-2-carboxylate and 121 μL (1.04 mmol) of benzoyl chloride instead of cyclopropanecarbonyl chloride. After treatment, 170 mg of beige solid is obtained (55%).

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-b50f91d4afa84744afb57697ebd29bed
Source dataset
uspto-grants-2013_11
Patent number
US08580815B2

Reaction notes

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