反应详情

A reactor is charged with 1.2 g (4.06 mmol) of the compound obtained in step 2, 0.55 g (4.88 mmol) of 3-dimethylaminopyrrolidine, 2.8 g (20.3 mmol) of potassium carbonate and 25 ml acetone. The mixture is heated for 6 hours at reflux. The solvent is evaporated under reduced pressure and 100 ml of water is then added. The obtained solution is extracted with 3*30 ml ethyl acetate. The organic phases are combined, dried on sodium sulphate and then evaporated under reduced pressure to give the expected product (0.8 g, 61%),

1. temperatureThe mixture is heated for 6 hours
2. temperatureat reflux
3. customThe solvent is evaporated under reduced pressure and 100 ml of water
4. additionis then added
5. extractionThe obtained solution is extracted with 3*30 ml ethyl acetate
6. customdried on sodium sulphate
7. customevaporated under reduced pressure