Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | HCID 68183016 | HCID 68183016 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 68075551 | HCID 68075551 | — |
Reaction Steps
R102 (784 mg, 1.76 mmol) is treated with THF (7.0 mL), methanol (1.5 mL), water (3.0 mL), and lithium hydroxide monohydrate (222 mg, 5.28 mmol) and the resulting mixture is stirred at 40° C. for 1.5 hours. The mixture is then treated with 1N hydrochloric acid (5.28 mL, 5.28 mmol) and concentrated in vacuo to afford R103 (960 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08580829B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-4ab3f196e74d496f925f97d549d60eda |
|---|
| Source note | uspto-grants-2013_11 |
|---|
