Hydrochloric Acid → HCID 68075551, compound

HRID 2040024Notes

Reaction equation

HRID 2040024 reaction equation
C([O:3][C:4](=[O:33])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[O:15][N:14]=[C:13]([C:16]3([C:20]4[CH:25]=[CH:24][C:23]([C:26]5[CH:27]=[N:28][C:29]([NH2:32])=[N:30][CH:31]=5)=[CH:22][CH:21]=4)[CH2:19][CH2:18][CH2:17]3)[N:12]=2)[CH:8]=[N:7]1)C.C1COCC1.O.[OH-].[Li+].Cl>O.CO>[NH2:32][C:29]1[N:30]=[CH:31][C:26]([C:23]2[CH:24]=[CH:25][C:20]([C:16]3([C:13]4[N:12]=[C:11]([C:9]5[CH:8]=[N:7][N:6]([CH2:5][C:4]([OH:33])=[O:3])[CH:10]=5)[O:15][N:14]=4)[CH2:19][CH2:18][CH2:17]3)=[CH:21][CH:22]=2)=[CH:27][N:28]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 68183016HCID 68183016, compound

Product 1

HCID 68075551HCID 68075551, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

R102 (784 mg, 1.76 mmol) is treated with THF (7.0 mL), methanol (1.5 mL), water (3.0 mL), and lithium hydroxide monohydrate (222 mg, 5.28 mmol) and the resulting mixture is stirred at 40° C. for 1.5 hours. The mixture is then treated with 1N hydrochloric acid (5.28 mL, 5.28 mmol) and concentrated in vacuo to afford R103 (960 mg).

Workup

  1. concentrationconcentrated in vacuo
  2. customto afford R103 (960 mg)

Sources & evidence

ORD record
ord-4ab3f196e74d496f925f97d549d60eda
Source dataset
uspto-grants-2013_11
Patent number
US08580829B2

Reaction notes

Loading…