Vanillin → 4-(2-Chloro-4-cyanophenoxy)-3-methoxybenzaldehyde

HRID 2040096Notes

Reaction equation

HRID 2040096 reaction equation
[O:1]=[CH:2][C:3]1[CH:11]=[CH:10][C:8]([OH:9])=[C:5]([O:6][CH3:7])[CH:4]=1.[Cl:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1F)[C:16]#[N:17]>>[Cl:12][C:13]1[CH:14]=[C:15]([C:16]#[N:17])[CH:18]=[CH:19][C:20]=1[O:9][C:8]1[CH:10]=[CH:11][C:3]([CH:2]=[O:1])=[CH:4][C:5]=1[O:6][CH3:7]

Participants

3

Reactant 2

HCID 1183VanillinHCID 1455253-Chloro-4-fluorobenzonitrile

Product 1

HCID 510515014-(2-Chloro-4-cyanophenoxy)-3-methoxybenzaldehyde

Procedure

4-(2-Chloro-4-cyanophenoxy)-3-methoxybenzaldehyde was prepared from vanillin and 3-Chloro-4-fluorobenzonitrile following General Procedure A. 1H NMR (400 Hz, CDCl3) δ 9.95 (s, 1H), 7.76 (d, 1H), 7.56 (br s, 1H), 7.50 (d, 1H), 7.45 (brd, 1H), 7.15 (d, 1H), 6.78 (d, 1H), 3.90 (s, 3H).

Sources & evidence

ORD record
ord-884de01f6656428abfc91a8821b7f9b2
Source dataset
uspto-grants-2013_11
Patent number
US08580832B2

Reaction notes

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