Methyl iodide → HCID 69041534, compound

HRID 2040102Notes

Reaction equation

HRID 2040102 reaction equation
[CH3:1][O:2][C:3]1[CH:21]=[C:20]([CH:22]=[C:23]2[S:27][C:26](=[S:28])[NH:25][C:24]2=[O:29])[CH:19]=[CH:18][C:4]=1[O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][C:7]=1[C:14]([F:17])([F:16])[F:15].[CH3:30]I.[Al]>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:21]=[C:20]([CH:22]=[C:23]2[S:27][C:26]([S:28][CH3:30])=[N:25][C:24]2=[O:29])[CH:19]=[CH:18][C:4]=1[O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][C:7]=1[C:14]([F:17])([F:16])[F:15]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 5359268AluminumHCID 86623142HCID 86623142, compound

Product 1

HCID 69041534HCID 69041534, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-[2-Methoxy-4-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-phenoxy]-3-trifluoromethyl-benzonitrile (500 mg, 1.15 mmol) in DMF (5 mL) was added CH3I (15 mL) and the solution was heated to 40° C. in an aluminum heating block for 8 h. The solvent was concentrated in vacuo to afford the product. 1H NMR (400 Hz, CDCl3) δ 7.97 (bs, 1H), 7.68 (dd, 1H), 7.63 (s, 1H), 7.17 (m, 3H), 6.77 (d, 1H), 3.08 (s, 3H), 2.95 (s, 3H).

Workup

  1. concentrationThe solvent was concentrated in vacuo
  2. customto afford the product

Sources & evidence

ORD record
ord-9f1cab2ac874430a90be52fcb54ec39f
Source dataset
uspto-grants-2013_11
Patent number
US08580832B2

Reaction notes

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