Hydrochloric Acid → 3-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

HRID 2040159Notes

Reaction equation

HRID 2040159 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1)([O-:3])=[O:2].Cl>ClCCl.CCOCC>[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([NH2:11])(=[O:12])=[O:13])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67126453HCID 67126453, compound

Product 1

HCID 433458063-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 4-(2-nitro-4-sulfamoylphenylamino)piperidine-1-carboxylate was dissolved in dichloromethane (3 mL) and treated with 1N HCl in ether (4 mL). The reaction was stirred overnight then concentrated to give the title compound.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-2e1ba38ec41b455087599ca1a01103cd
Source dataset
uspto-grants-2013_11
Patent number
US08580794B2

Reaction notes

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