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HRID20402

反应详情

EQUATION

反应方程式

HRID 20402 的结构方程式

REACTANTS

反应物

1
结构：C[C@H]1[C@H](OCC(C)(C)C)OC[C@H](COCc2ccccc2)N1C(=O)OC(C)(C)C
HCID68561777

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H]1[C@H](OCC(C)(C)C)OC[C@H](CO)N1C(=O)OC(C)(C)C
HCID68563537

未命名化合物

收率 93.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Stir (2R,3S,5S)-5-benzyloxymethyl-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester (0.65 g, 1.59 mmol) and 20% palladium hydroxide on carbon (0.65 g) in methanol (25 mL) under a hydrogen atmosphere at room temperature for 2 hours. Filter through Celite®, concentrate and purify (silica gel chromatography, eluting with 0:100 to 20:80 ethyl acetate:hexanes) to give the desired compound as an oil (471 mg 93.0%).

WORKUP

后处理

  1. filtrationFilter through Celite®
  2. concentrationconcentrate
  3. custompurify
  4. wash(silica gel chromatography, eluting with 0:100 to 20:80 ethyl acetate:hexanes)