Trifluoroacetic acid → HCID 67126745, compound

HRID 2040316Notes

Reaction equation

HRID 2040316 reaction equation
[C:1]([C:3]1([CH3:18])[CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1)#[N:2].FC(F)(F)C(O)=O>ClCCl>[NH2:10][CH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH3:18])([C:1]#[N:2])[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86648183HCID 86648183, compound

Product 1

HCID 67126745HCID 67126745, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 366A (480 mg) in dichloromethane (10 mL) was added trifluoroacetic acid (10 mL). The mixture was stirred for 3 hours. The mixture was then concentrated under vacuum and was used directly in the next reaction without further purification.

Workup

  1. concentrationThe mixture was then concentrated under vacuum
  2. customwas used directly in the next reaction without further purification

Sources & evidence

ORD record
ord-a02b4d2b9f344938b4575f553f884377
Source dataset
uspto-grants-2013_11
Patent number
US08580794B2

Reaction notes

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