HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2040344Generated: October 30, 2026
Methanol → N-(2-chloro-4-sulfamoylphenyl)-4-methoxypiperidine-1-carboxamide
https://huagongshe.com/reaction/2040344
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Methoxypiperidine | HCID 77666 | — |
| Reactant | 3-Chloro-4-isocyanatobenzenesulfonamide | HCID 86653693 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2-chloro-4-sulfamoylphenyl)-4-methoxypiperidine-1-carboxamide | HCID 67126739 | — |
Reaction Steps
To a solution of EXAMPLE 392A in anhydrous tetrahydrofuran (6 mL) was added 4-methoxypiperidine (451 mg). The mixture was stirred at 60° C. for 3 hours. The mixture was cooled, mixed with methanol (20 mL) and silica gel (6 g) and concentrated. The material was purified on a silica gel column and was eluted with 10% methanol in dichloromethane to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08580794B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-8cdf913c37914fdb94b260c67ac55347 |
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| Source note | uspto-grants-2013_11 |
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