反应详情

温度

60 °C

To a solution of EXAMPLE 392A in anhydrous tetrahydrofuran (6 mL) was added 4-methoxypiperidine (451 mg). The mixture was stirred at 60° C. for 3 hours. The mixture was cooled, mixed with methanol (20 mL) and silica gel (6 g) and concentrated. The material was purified on a silica gel column and was eluted with 10% methanol in dichloromethane to provide the title compound.

1. temperatureThe mixture was cooled
2. concentrationconcentrated
3. customThe material was purified on a silica gel column
4. washwas eluted with 10% methanol in dichloromethane