反应详情

1.9 g (4.5 mmol) of the intermediate from Step D and 1.75 g (9.5 mmol) 1-(1-methylpiperidine-4-yl)-piperazine were dissolved in 30 ml dry THF and refluxed for 90 minutes. The volatiles were removed in vacuo. The resulting residue was dissolved in ethyl acetate, washed with H2O and dried over magnesium sulfate and the solvent was removed in vacuo. The residue was treated with H2O and the resulting precipitate was separated to yield 1.5 g of the intermediate.

1. temperaturerefluxed for 90 minutes
2. customThe volatiles were removed in vacuo
3. dissolutionThe resulting residue was dissolved in ethyl acetate
4. washwashed with H2O
5. dry with materialdried over magnesium sulfate
6. customthe solvent was removed in vacuo
7. additionThe residue was treated with H2O
8. customthe resulting precipitate was separated