Benzosuberone → 9-Methoxy-5,6,7,12-tetrahydro-benzo[6,7]cyclohepta[1,2-b]indole

HRID 2040451Notes

Reaction equation

HRID 2040451 reaction equation
[CH:1]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11](=O)[C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22]N)=[CH:18][CH:17]=1>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]2[C:19](=[CH:20][CH:21]=1)[NH:22][C:11]1[C:5]3[CH:4]=[CH:3][CH:2]=[CH:1][C:6]=3[CH2:7][CH2:8][CH2:9][C:10]2=1

Participants

3

Reactant 2

HCID 70003BenzosuberoneHCID 27239044-Methoxyphenylhydrazine hydrochloride

Product 1

HCID 596760379-Methoxy-5,6,7,12-tetrahydro-benzo[6,7]cyclohepta[1,2-b]indole

Procedure

Following the procedure described in Example 4, using 6,7,8,9-tetrahydro-benzocyclohepten-5-one (1.10 g, 6.87 mmoL) and 4-methoxy-phenylhydrazine HCl salt (1.20 g, 6.87 mmoL) as the starting material, the title compound was prepared as a brown solid.

Sources & evidence

ORD record
ord-e9db6d984be14b66bc39d1b76dc85d2f
Source dataset
uspto-grants-2013_11
Patent number
US08580840B2

Reaction notes

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