反应详情

温度

70 °C

A suspension of N-(2-nitro-4-oxetan-3-ylphenyl)acetamide (125 mg, 0.529 mmo) in aqueous hydrazine (8 ml, 160 mmol) was heated at 70° C. for 2 h, the reaction mixture was cooled to 45° C. and the hydrazine was removed in vacuo to yield a solid. The crude material was purified by flash chromatography (SiO2, eluting with 20% EtOAc/CH2Cl2 to yield the desired product (71 mg).

1. temperaturethe reaction mixture was cooled to 45° C.
2. customthe hydrazine was removed in vacuo
3. customto yield a solid
4. customThe crude material was purified by flash chromatography (SiO2
5. washeluting with 20% EtOAc/CH2Cl2