Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | N-(2-nitro-4-(oxetan-3-yl)phenyl)acetamide | HCID 67776164 | — |
| Product | 2-Nitro-4-(oxetan-3-YL)aniline | HCID 67775173 | 69.1% |
Reaction Steps
A suspension of N-(2-nitro-4-oxetan-3-ylphenyl)acetamide (125 mg, 0.529 mmo) in aqueous hydrazine (8 ml, 160 mmol) was heated at 70° C. for 2 h, the reaction mixture was cooled to 45° C. and the hydrazine was removed in vacuo to yield a solid. The crude material was purified by flash chromatography (SiO2, eluting with 20% EtOAc/CH2Cl2 to yield the desired product (71 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08580762B2 |
|---|
| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-559cf7b05f9c4b828b479a9c4396331b |
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| Source note | uspto-grants-2013_11 |
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