HCID 178499428, compound → HCID 178513299, compound

HRID 2040799Notes

Reaction equation

HRID 2040799 reaction equation
[OH:1][NH:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]C)=[O:13])=[CH:7][CH:6]=1)=[NH:4]>Cl>[OH:1][NH:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1)=[NH:4]

Participants

3

Reactant 1

HCID 178499428HCID 178499428, compound

Product 1

HCID 178513299HCID 178513299, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of methyl [4-(N-hydroxycarbamimidoyl)-phenyl]-acetate (3.67 g, 17.6 mmol) in 25% aq. HCl (15 mL) is stirred at 65° C. for 4 h. The solvent is removed in vacuo and the residue is dried under high vacuum to give [4-(N-hydroxycarbamimidoyl)-phenyl]-acetic acid (3.80 g, presumably as hydrochloride) as a yellow solid; LC-MS: tR=0.34 min, [M+1]+=195.05.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe residue is dried under high vacuum

Sources & evidence

ORD record
ord-69b6234bc94046ea9b4fe7097771277d
Source dataset
uspto-grants-2013_11
Patent number
US08580824B2

Reaction notes

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