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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2040808Generated: October 31, 2026

HCID 86639881, compound → 3-{2-Ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid

https://huagongshe.com/reaction/2040808

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 86639881HCID 86639881—
SolventHydrochloric AcidHCID 313—
Product3-{2-Ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acidHCID 59234747—

Reaction Steps

A solution of the above 3-{2-ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid tert. butyl ester in 6 N aq. HCl (10 mL) is stirred at 65° C. for 18 h. The solvent is evaporated and the residue is suspended in MeCN. The solid material is collected, washed with additional MeCN and dried under high vacuum to give 3-{2-ethyl-4-[5-(2-ethyl-6-methyl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-6-methyl-phenyl}-propionic acid (135 mg) as a white powder; LC-MS: tR=0.86 min, [M+1]+=380.13.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08580824B2
Source datasetuspto-grants-2013_11
ORD IDord-b52515d8958c42e6881c61f1128974a0
Source noteuspto-grants-2013_11